To determine the significance of the study in thesis, we must first consider what a thesis actually is; A thesis is defined in this case as a dissertation on a particular subject in which original research has been done, presented by a candidate for a diploma or degree &/or a proposition stated for consideration, particularly one to be discussed and proved or maintained against opposing views. The significance of your study in your thesis is whatever you have deemed it to be. You decide the significance of your study and the better you can articulate this, the stronger your thesis will be.
You have been assigned a thesis study as a graduation requirement and know exactly what you want to do with it and why, you are far beyond the average student and already fully understand the significance of your study and how you will present it. Others of us have to mull it over a few thousand times before we can decide a direction to take with it. Say your field of study is in IT management and you are writing a thesis on virtual and cloud computing as compared to individual physical machines and infrastructure. You could make the argument that the versatility, ease of use, time benefits, overhead cost reduction and 24 hour availability of these cloud systems built with virtual platforms on a reduced amount of servers provide a more robust and scalable backbone for any business regardless of industry. The significance of this would be the cost reduction, the scalability; all of these emphasize the significance of your thesis.
Ultimately, these decisions will be made between you and your thesis adviser. Choosing a thesis study that you are passionate about and are excited to research will make the work of putting an exceptional paper together seem effortless.